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Furthermore, by promoting Nrf2 expression and activating HO-1, it significantly reduces ROS levels and MDA content in the kidneys of AKI rats, increases levels of GSH, GPX4, and other anti-ferroptosis proteins, markedly reduces the number of apoptotic cells in the kidneys and renal tubular epithelial cells of model rats, and promote the expression levels of pro-apoptotic proteins, thereby protecting the kidneys (181)

While there were no clear signs of toxicity, mice treated with fruit essential oils at doses of 1,000 and 2,000 mg/kg displayed passive behavior during the first 24 h

Moreover, their primary role is to reduce peroxides, protecting cells from oxidative damage and maintaining cellular integrity

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