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Gaps in safety assessment encompass limited long-term data in vulnerable populations, an incomplete understanding of horizontal gene transfer related to antimicrobial resistance, and uncertainty regarding the systemic impact of prolonged microbiome modulation, particularly with next-generation strains lacking a long history of safe use (142)

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A fund that invests in Underlying ETFs may provide returns that are lower than the returns that an investor could achieve by investing in one or more Underlying ETFs alone and the fund bears its proportionate share of each ETFs expenses, subjecting fund shareholders to duplicative expenses