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The protein expression of ROCK1 and ROCK2 were significantly higher in hypertension-associated ED rats than that in the normal control rats, with a reduction of endothelial NOS, cGMP, and an elevation of norepinephrine-induced hyper-contractions, and acetylcholine-induced hypo-relaxations in the penile tissue [118]

Microbiome dysfunction is associated with the pathology of several conditions, including obesity, depression, and autoimmune disorders such as type 1 diabetes, rheumatoid arthritis, muscular dystrophy, multiple sclerosis, and fibromyalgia

regulates cellular redox state through the GSH:GSSG couple

Wikman, H