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Immunocytes can be considered as important target cells of TG, which, if necessary, can produce and deposit TSH and T3, have receptors for these hormones and related genes, which makes them capable of forming new endocrine glands ( Mechanisms underlying the action of TG include both genomic (via nuclear receptors) and non-genomic (membrane) effects

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There is a lifelong dependence on blood transfusions for survival, with the associated risk of iron overload