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However, GLP-/GIP dual agonists have been proved to be orally effective in animal experiments, and its state in plasma is more stable than GLP-1RA [141], and this oral administration method has gradually been applied to the clinic [142]

Specifically, NUSAP1-K34la facilitates its interaction with c-Myc and HIF-1, thereby forming a transcriptional regulatory complex that localizes to the lactate dehydrogenase A (LDHA) promoter and upregulates its expression

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