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Additionally, TRAIL-R signaling may disrupt key metabolic pathways like glycolysis and fatty acid oxidation, impairing MDSC function

According to consensus guidelines for the assessment of oxidative stress biomarkers, the multi-parametric evidence of oxidative damageparticularly the lipid peroxidation products identified through advanced techniques such as mass spectrometrymay provide supportive evidence of potential redox imbalance and reduced antioxidant capacity in PEM patients (104)

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