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There are three major causes of migraine which are Vascular (due to cerebral vasodilatation), Ineurological (abnormal neurological firing which causes the spreading depression and migraine) and Neurogenic dural inflammation (release of inflammatory neuropeptides) In this combination, Magnesium plays an important role in mitochondrial energy production, and magnesium deficiency can lead to many physiological changes, including cerebral artery spasm and increased release of pain mediators