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Their symptoms were being driven by bacterial imbalances, SIBO, or other factors entirely

Our data highlight that efflux pumps should be revisited as promising intervention points to enhance the effectiveness of small molecule inhibitors in leukemia and beyond

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While Nrf2 and JAK2/STAT3 are indeed activated as protective responses during MIRI, the overwhelming and dynamic nature of the oxidative insult often impairs their full protective capacity or overwhelms the defense mechanisms they regulate, leading to a functional failure in restoring redox balance