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In some embodiments, the otic formulation or composition comprises between about 0.1% to about 40% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof

In practice, it is a chemically sensitive process that can influence experimental outcomes if not properly understood

Currently, there is no specific treatment for PVL, but many studies try to find specific agents to attenuate white matter damage by preventing cell death of pre-oligodendrocytes

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