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These highly reactive molecules can damage cell membranes and proteins, which in turn can lead to premature ageing and cell damage

ERO1A is a FAD-dependent enzyme catalyzing the oxidative folding (formation of disulfide bonds) of secretary proteins in the ER 42,43

This suggests that melatonin either has an independent effect or works synergistically with GA and betaine to improve glycemic control in the experimental animals

These results indicate that riboflavin status modifies the associations between the polymorphisms studied and tHcy and that the effects of the polymorphisms on tHcy depend on interactions between riboflavin and the substrates of the corresponding enzymes