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Nobiletin, a flavonoid derived from citrus peels, helps modulate peripheral clocks

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In addition, they influence metabolism by inhibiting liver enzymes, such as cytochrome P450, reducing artemisinin degradation and prolonging its activity in the body [175,176,177], as well as by increasing artemisinins availability at its site of action by interacting with cellular transporters, therefore amplifying its therapeutic effects [176,178]