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Clinical manifestations of essential fatty acid deficiency primarily include skin effects (i.e., dermatitis), but negative hematologic effects and impaired immunity have also been seen in humans (96)

The dose of APAP could be increased to 100 mg/kg/day as described in various studies 40,47 , but this dose has been shown to induce hepatic toxicity in rodents and pigs after 5 consecutive days 23