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Esculetin as a coumarin compound in various plants exhibited strong anti-inflammatory effect, reduced the levels of IL-1, IL-6, and TNF- in serum and hippocampus, and down-regulated the hippocampal expression of iNOS and COX-2 in LPS-depressed mice (97)

84 A well-controlled clinical trial demonstrated that, when added to a diet low in saturated fat and cholesterol, pantethine provided an additional reduction in total cholesterol and LDL

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