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It was first identified as a factor that accelerated wound healing, but research quickly expanded to show roles in collagen stimulation, angiogenesis, and gene expression

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Its history began with a breakthrough by a research team at the University of Texas, USA, in 2017.At that time, NNMT was recognized as a key enzyme in cellular metabolism and energy homeostasis, highly active in adipose tissue and closely linked to obesity, type 2 diabetes, and other metabolic diseases

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