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However, various in vitro experiments revealed CSC-induced cellular atherogenic alterations in endothelial cells as for instance: (a) genotoxic effects, 35 (b) alteration in the cytokine expression, 36 (c) upregulation of genes involved in matrix degradation, 37 (d) CSC-induced adherence of monocytes to the endothelial cell monolayer, 38 (e) CSC-induced surface expression of adhesion molecules on endothelial cells and transendothelial migration of monocytes 39 and (f) decreased migration ability of endothelial cells in vitro
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JTI is expanding its American Spirit brand with the launch of American Spirit Essential Blue roll your own (RYO) tobacco, which comes in a 30g format and a new paper pouch
Made without additives or chemicals in the manufacturing process and feature the same great New York New York taste.
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