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Such a pathophysiology-agnostic regimen avoids the single pathway paradigm that might underlie the failure of many disease-modifying efforts in unselected populations 169

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The coolest prop in film history, the glamorous accessory of Hollywood's golden age (even if it was part of a grander mercantile scheme), beloved by film-makers for the ethereal arabesques of grey its combustion produces, the cigarette has been used to signify many things to men and women alike: from poise to threat, from masculinity to fashion statement, from rebellion to seduction, and so on

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