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For someone on a 0.25mg weekly dose, that is a 40-60% dosing error from a nearly invisible syringe misread

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Whether those concentrations are high enough to reliably activate receptors at the ultra-low end (0.25-0.5 mg) is genuinely uncertain

HSC activation is associated with metabolic reprogramming toward mitochondrial oxidative phosphorylation 41 , whereas activation of differentiated myeloid cell is associated with increased glycolysis 43