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It is popular globally and genuinely interesting, but the human clinical evidence varies widely by route and dose so we include it for its antioxidant rationale within the formula rather than as the reason the treatment works

Hypoxia stimulates the expression of HO-1 [206] in cultured trophoblastic cells, and is used to detect increased OS therein [207]

Furthermore, descending inhibitory pathways, which modulate the visceral pain signal by releasing neurotransmitters such as opioids, noradrenaline, dopamine and 5-HT [94], are down-regulated in IBS patients as indicated by an increased somatic sensitivity [95]

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