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They are proposed to trigger the disease process by activating glial cells, impairing synaptic plasticity, and inducing neuronal toxicity

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3 Mechanisms of action of natural supplements against breast cancer 3.1 Anti-inflammatory and antioxidant pathways The chronic inflammatory microenvironment in the breast activates nuclear factor-B (NF-B), cyclooxygenase-2 (COX-2), signalling transducers and activators of transcription-3 (STAT3), activator protein-1, and mitogen-activated protein kinase signalling cascades

In human samples, mitochondrial superoxide dismutase 2 associates with PCa risk and Gleason score, suggesting LPA signaling may affect tumor progression through redox balance regulation (74)