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Reviews published in 2025 describe a body of research dominated by animal and cell studies, with signals suggesting effects on angiogenesis (the growth of blood vessels), growth-factor signalling (mainly growth hormone) and musculoskeletal healing

Rhonda: where youre getting cross-disciplinary youre getting this Gordon: Yeah

doi: 10.1038/nrn.2018.19 214 MagkoutaS.VeroutisD.PapaspyropoulosA.GeorgiouM.LougiakisN.PippaN.et al

Role of 1C Metabolism in Redox Balance in Relation to Aging The redox theory of aging presents an intriguing perspective on how longevity may be influenced by the cellular redox state, specifically through the ratios of GSH (glutathione) to GSSG (oxidized glutathione) and of NADP+ to NADPH [129]