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Under physiological conditions, astrocytes support synaptic transmission by efficiently clearing glutamate via excitatory amino acid transporters (EAAT)1/2 106 , converting it into glutamine and supplying lactate to neurons through aerobic glycolysis 107

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Under normoxia and high glucose availability, most acetyl-CoA is produced from glucose-derived pyruvate via pyruvate dehydrogenase and exported as citrate for lipid synthesis