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Notably, researchers have documented that the peptide appears to upregulate NO production when it is deficient and downregulate it when excessive, suggesting a modulatory rather than simply stimulatory relationship

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Its ability to cross the bloodbrain barrier in laboratory models, combined with a relatively long plasma half-life compared to other small neuropeptides, has contributed to its enduring relevance in neurochemistry research

4,74 In addition, networks that connect the auditory system with other brain regions may become involved