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John Myers in the 1960s and refined through decades of clinical use across conditions including chronic fatigue, migraines, fibromyalgia, and weakened immunity

Interestingly, many of the patient-specific genes we found expressed in organoids and their source cells had been associated with susceptibility to several liver diseases, including hepatitis virus infection ( IL1RL1 and ERAP2 ), liver cancer ( GPC3 ) and cholestasis during pregnancy ( GABRP )

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These mice also exhibited decreased pro-inflammatory cytokines such as TNF-alpha, IL-1, IL-6, and INF- and increased anti-inflammatory cytokines, IL-10, and IL-4