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In some embodiments, the otic formulation or composition comprises about 12% by weight of the poloxamer

10.4049/jimmunol.176.4.2238 141 NakamuraY.IshimaruK.ShibataS.NakaoA

That same pilot study found natural killer (NK) cell activity, a frontline part of your immune system, increased by as much as 400% at the two-week mark, alongside a 60% rise in lymphocyte proliferation