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2.2 Promotion of metabolism In postmenopausal women and the OVX rat model, a reduction in estrogen levels has been linked to the onset of central obesity, dyslipidemia, insulin resistance, and an elevated risk of developing non-alcoholic fatty liver disease, type 2 diabetes, and cardiovascular disease (10, 38, 39)

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The synthetic triterpenoid RTA dh404 (CDDO-dhTFEA) restores endothelial function impaired by reduced Nrf2 activity in chronic kidney disease

The calcium sodium derivative of EDTA, administered intravenously, has been employed for treating mercury and lead poisoning