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Notably, vitamin B12 plays a pivotal role in the health and maintenance of nerve cells, the formation of red blood cells, and the intricate process of DNA synthesis

In SCA3, progression is slow and the disease does not affect development (contrary to several pediatric genetic disorders) [183]: ethically, this supports the feasibility of a robust clinical trial

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A vial isnt just 5mg or 10mg in isolation that mass has to be matched against the intended use volume, and the same mass can support meaningfully different concentrations depending on how much diluent is introduced