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NNMT metabolizes nicotinamide into 1-methylnicotinamide (MNA), diverting it away from the NAD+ salvage pathway

Your clinician sets the schedule, and the same NHS management guidance is used across services to keep it consistent

For confirmed B12 deficiency without neurological involvement , the standard regimen comprises 1 mg hydroxocobalamin intramuscularly three times weekly for two weeks, followed by maintenance doses every two to three months for those with irreversible causes like pernicious anaemia