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Overall, GPX4 inhibitors could have a combined effect on eliminating senescent cells in the tumour and tumour microenvironment and the subset of highly plastic, mesenchymal-like cells that promote therapy resistance

A randomized, double-blind, placebo-controlled trial of glutathione supplementation (500 mg/day oral) over 4 weeks documented significant reductions in melanin index at multiple body sites, with the greatest effect on sun-exposed areas (Arjinpathana & Asawanonda, 2012)

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Under a simulated TME, MOF-919@CCM exhibited POD-like catalysis, CAT-like oxygen production, and photo-triggered ROS generation