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These molecules can be receptors/transporters substrates, substrate derivatives, substrate-binding moiety fragment molecules, antibodies or antibody-binding fragments against the receptors/transporters

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Their active center is a conserved tetramer composed of selenocysteine residues (Sec), glutamine (Gln), tryptophan and asparagine

This disease state provides an ideal model to illustrate the pivotal role of intra-portal insulin as the key regulator of the GH/IGF-I axis