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We summarize the efficacy, limitations, and impact on the E-P-OS network of the following drugs in Table 3

In a study of 10 healthy male volunteers, omeprazole, in doses of 20 mg-40 mg per day, caused a significant decrease in the oral absorption of methylcobalamin, vitamin B12

Additionally, treatment with 5-HT 2C antagonists enhances ghrelin-induced food intake, whereas treatment with lorcaserin, a 5-HT 2C agonist, decreases ghrelin-induced food intake (Schellekens et al., 2015)

In an acidic environment, myoglobin readily passes through glomerular filtration and accumulates in kidney tubules, and it is also easy to interact with Tamm Horsfall protein and precipitate in the renal tubules, thereby inducing lipid peroxidation and producing prostaglandins, resulting in renal arteriolar dysfunction and hypoperfusion