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The higher concentrations of ATP, NAD + , and NADH could explain why the gdh3 / gdh3 mutant remained in the yeast form in arginine medium (hyphae-inducing conditions)

These in vitro studies in monolayers with cancer-derived cell lines differ radically from the situation in vivo in the normal intact intestinal epithelium with numerous specialized cell types, intact blood and lymphatic circulations, and other structures and factors such as the glycocalyx, secreted mucus, reticuloendothelial cells, other immune cells, and mesenteric nerves