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Efficacy steadily declines as drug concentration drops, halving every 3-4 hours thereafter

Indeed, according to a recent CDC study, more than a quarter-million middle and high school students who had never smoked said they had used e-cigarettes in 2013

Nicotine binds directly to nicotinic acetylcholine receptors in your prefrontal cortex, causing dopamine neurons in your ventral tegmental area to increase their firing rates