Treatment of acute stroke has advanced significantly over the last decade, especially in developed countries, greatly reducing mortality and improving patients functional outcomes (Dirnagl et al., 1999), metaplasticity (Murphy and Corbett, 2009), the activation of molecular, multi-omics pathways (Montaner et al., 2020), immune responses ( An intriguing and potentially therapeutically relevant effect of stroke is the robust stimulation of neurogenesis in the adult brain (Gu et al., 2000)
theoretical concern about fueling tumor growth through enhanced bioenergetics and DNA repair in malignant cells Long-term data: Limited to supplement-duration studies (typically 2-12 weeks)
Therapeutic Research Protocol Dose: 1.2 2.4 mg (= 4896 clicks) Duration: 12 20 weeks Frequency: Once weekly Cycle Interval: 4 6 weeks off before repeating Goal / Description: Higher-dose protocol used in obesity research to evaluate sustained satiety and adiposity reduction
To conclude, BBB alterations could influence not only pathology and progression of PD but also therapeutic interventions
