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Copper homeostasis, like the homeostasis of other transition metals, 120 is tightly controlled by the combined action of transcriptional regulators that sense copper levels (Section 3), efflux pumps, storage proteins and metallochaperones, the latter of which allocate Cu to partner proteins without dissociation into solvent

It should also be noted that before approving our protocols, the IRB engaged a second external expert who did not share the concerns regarding clinical equipoise

This tool may assist in the early detection of silent infarctions and guide preventive treatment decisions

Researchers should monitor experimental subjects closely