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1 Introduction Vitamins of the B complex comprise a group of eight water-soluble vitamins that play a crucial role in maintaining optimal neurological function, such as energy production, DNA/RNA synthesis/repair, genomic and non-genomic methylation, and synthesis of neurochemicals ( Figures 1 , 2 ) ( Figure 1 Figure 2 Thiamine (B1) deficiency is often associated with beriberi, a syndrome mainly characterized by polyneuritis and/or cardiovascular symptoms ( In conclusion, B vitamins are essential for both catabolic and anabolic metabolism functioning as coenzymes in numerous processes vital to cellular physiology, including brain and nervous system activities ( Table 1 )

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The extensive changes in the levels of these cytokines and chemokines are most likely due to the imbalance in the Th1/Th17 and Treg cell subsets in patients with MS