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doi: 10.1371/journal.pone.0247237 20

500 mg/L) similarly did not alter expression of commonly used hepatic transcriptional biomarkers in zebrafish larvae, including mt2 (metallothionein 2), vtg1 (vitellogenin 1), and cyp1a [154]

Their expression leads to post-transcriptional silencing of target genes by mRNA translation repression

For example, ECM proteins crucial for cartilage structure and maintenance, such as ACAN, DCN, HSPG2, BGN, and FBLN1 were downregulated in the conditioned medium of H 2 O 2 -treated cells compared to those in control cells