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Limitations of Use Hydrocodone Bitartrate and Acetaminophen Tablets are contraindicated in patients with: Significant respiratory depression [see WARNINGS] Acute or severe bronchial asthma in an unmonitored setting or in the absence of resuscitative equipment [see WARNINGS] Known or suspected gastrointestinal obstruction, including paralytic ileus [see WARNINGS] Hypersensitivity to hydrocodone or acetaminophen (e.g., anaphylaxis) [see WARNINGS,ADVERSE REACTIONS] Hydrocodone Bitartrate and Acetaminophen Tablets contains hydrocodone, a Schedule II controlled substance

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Pure vitamin C, known as L-ascorbic acid, is the most effective antioxidant when formulated correctly

9,10 As discussed above, MRP2 is not as specific for bile salts and is also responsible for primary conjugated bilirubin excretion as well as various substrates and drugs