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Josef Penninger, professor and director of the Life Sciences Institute at the University of British Columbia, said that This is an interesting correlation that has been also noted in earlier published data from China. Ankit Patel, a nephrology fellow at Brigham and Womens Hospital in Boston, also found that the suggestion that nicotinic acetylcholine receptors could modulate SARS-CoV-2 neuroinfection is interesting. However, he cautioned that this has yet to be tested. Penninger also pointed out that these studies have not provided evidence that smoking reduces ACE2 levels in cells, and that the proposed mechanism by Changeux et al

They all have the same basic internal system shown below

they couldn't do it, flat couldn't do the thing