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doi: 10.1371/journal.pone.0067617 321 NimmerjahnAKirchhoffFHelmchenF

The typical outcome measure used by researchers is the Sciatic Function Index that assesses hind limb motor function based on toe to toe and toe to heel distance

G.SapolskyR

IL-1R not only competitively inhibits IL-1 binding to its receptor, thereby disrupting IL-1-induced osteoclastogenesis, but also directly interacts with integrin 3, activating downstream -catenin signaling and inducing the expression of osteogenic markers (100)