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We synthesize cross-system disease evidencebrain (hypoxia/ischemia, neuroinflammation), heart (divergent roles in acute ischemiareperfusion versus chronic failure), kidney (mitochondrial dysfunction and cGASSTING(cyclic GMPAMP synthasestimulator of interferon genes)driven fibrosis), gastrointestinal tract (stage-specific effects in colorectal cancer and impaired detoxification in ulcerative colitis), bone/metabolic disorders, and the male reproductive systemhighlighting SQORs bidirectional pathology when hydrogen sulfide is excessive or depleted

Log fold-changes and associated uncorrected and corrected p-values can be found in Supplementary Data 4, 9 and 12

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Singh A, Mahajan R, Kedia S, Dutta AK, Anand A, Bernstein CN, et al