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GSH regeneration is catalyzed by glutathione reductase using GSSG and NADPH generated by the pentose phosphate pathway (PPP, also called hexose monophosphate shunt, which also produces pentose phosphate sugars used in nucleotide synthesis.) The first reaction of the PPP, catalyzed by glucose 6-phosphate dehydrogenase (G6PD), is critical for producing an adequate amount of NADPH used in reductive biosynthetic pathways and importantly in the generation of GSH

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[DOI] [PubMed] [Google Scholar] 56.Bhat V

It increases the concentration of beta-hydroxybutyric acid by promoting ketogenesis in CD8+ cells, which follows upregulation of the hydroxybutyrate dehydrogenase (Bdh1) expression [98, 99]