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In conclusion, R-domain interactions lend a regulatory effect analogous to that of a transmission clutch that only engages an engine but otherwise does not perform thermodynamic work itself

A 2025 systematic review published in HSS Journal (Vasireddi et al.) reviewing BPC-157's use in orthopaedic sports medicine noted that preclinical data shows potential in musculoskeletal injuries but that human randomized controlled trial data remains absent