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290: G1269-G1279
When high doses of vitamin B 12 are given orally, only a small percentage can be absorbed, which may explain the low toxicity (4)
Injection Site Selection and Rotation: The abdominal area is the most common injection site for AOD-9604 due to accessibility and consistent absorption
Cyanocobalamin : Synthetic form, requires conversion to active B12, longer shelf life, lower cost Methylcobalamin : Bioactive form, immediate utilization, preferred for neurological symptoms, more expensive Hydroxocobalamin: Used for cyanide poisoning, longest-acting Standard dose: 1000mcg/ml Routes: Deep IM (gluteal/deltoid) or subQ (abdominal) Loading phase: Daily/weekly for 1-4 weeks Maintenance: Monthly or every 3 months (hydroxocobalamin) No need for aspiration before injection Oral absorption requires intrinsic factor (absent in pernicious anemia) and healthy ileum
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