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doi: 10.3389/fphar.2020.579944 Received 03 July 2020 Accepted 15 September 2020 Published 07 October 2020 Volume 11 - 2020 Edited by Leonello Fuso, Catholic University of the Sacred Heart, Italy Reviewed by Stephen C

Cell subpopulations with high OXPHOS activity consistently exhibit greater drug resistance, suggesting that mitochondrial metabolic heterogeneity may serve as a critical biomarker for resistance stratification and therapeutic classification [66]