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Products of lipid peroxidation4-Hydroxynonenal, malondialdehyde Polyunsaturated fatty acids (PUFAs) represent the main target of the lipid peroxidation process

S1c, d)

In dermal fibroblasts cultured from aged donors, GHK-Cu treatment (2 M) increases TIMP-1 mRNA expression by approximately 25%, contributing to reduced net collagenolytic activity and preservation of existing matrix structures

Although, SMCs and ECs synthesize MCP-1, SMCs also moves to the tunica intima from the tunica media, where they differentiate into myofibroblasts and increase in the presence of PDGF [183, 184] and insulin via ROS-dependent phosphorylation of serine residues of IRS-1 [185, 186]