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In this context, IDO1 expression might be associated with antitumor immune responses, as a marker of M1 macrophages, but not related to the enzymatic and anti-inflammatory activity of IDO1

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For comparison, we treated cells with tunicamycin (TUN, a widely-used ER stress inducer) which did not alter phospho-GCN2 (T899), but reduced the mobility of PERK, indicative of its increased phosphorylation (Fig

Biochem J 189:373376 Chew O, Whelan J, Millar AH (2003) Molecular definition of the ascorbateglutathione cycle in Arabidopsis mitochondria reveals dual targeting of antioxidant defenses in plants