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The 47kDa Akt substrate associates with phosphodiesterase 3B and regulates its level in adipocytes

(5) Research has shown that by preserving nicotinamide from NNMT-mediated degradation, the compound may enhance NAD+ synthesis through the salvage pathway

There is a theoretical case for using both in certain patients, targeting different physiological mechanisms simultaneously, though this approach is under evaluation and not yet standard of care