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There is also a theoretical concern that intramuscular injection might cause local tissue irritation or injection site reactions , though tirzepatide generally has a relatively low incidence of injection site adverse events in clinical trials

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It often results from the failure to eliminate the cause of an acute inflammation, an autoimmune response, or long-term exposure to irritants

Lymphocyte infiltration of exocrine glands, autoantibody production, and an imbalance in the inflammatory cytokine network drive disease progression, ultimately resulting in glandular dysfunction and multisystem involvement