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With the rapid development of sequencing technologies, large-scale metagenomic datasets have revealed that site-specific microbiota perform distinct biological functions within defined microenvironments 2,3,4,5 , highlighting the heterogeneity of microbial composition across anatomical sites and underscoring the need for a multi-organ perspective

Moreover, recruitment of pro-angiogenic myeloid cells is also considered to be a mechanism whereby tumors bypass the inhibitory effects of anti-angiogenics drugs

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