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Significant abnormal mitochondrial ultrastructure could be observed in Ddit4 Hep mice, as evidenced by decreased matrix density (asterisks) and abnormal mitochondrial morphology, such as swelling, deformation, and shrinking (arrows) (Fig
However, treatments with GABA, DSIP-CBBBP, and DSIP all resulted in increased struggle times compared to the model group, with CBBBP alone not showing a similar effect, indicating a differential impact on depressive-like behaviors and highlighting the potential therapeutic value of these treatments in addressing depressive symptoms associated with insomnia ( Figure 5 highlights the substantial influence of peptide treatments on the sucrose preference in mice disrupted by PCPA
Psychiatry 12:669089
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Other external cues, including feeding, physical activity, and social cues, have the capacity to entrain circadian rhythms as well, but generally less effectively as light (Aschoff et al., 1971
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